Journal Articles

Timing of Direct Oral Anticoagulants Resumption Following Colorectal Endoscopic Submucosal Dissection: A Nationwide Study in Japan

The American Journal of Gastroenterology |

Author: Chikamasa Ichita

This study investigates when to safely restart direct oral anticoagulants (DOACs) following colorectal endoscopic submucosal dissection (ESD), balancing risks of delayed bleeding versus thromboembolism.
Optimal DOAC management post-ESD is critical to prevent serious complications like gastrointestinal bleeding or thromboembolic events.
A nationwide, multicenter, retrospective cohort study analyzing timing of DOAC resumption and outcomes post-colorectal ESD in Japan.
Resuming DOACs on or after postoperative day 3 significantly reduces the risk of delayed bleeding without increasing thromboembolism risk.
Consider delaying DOAC resumption until postoperative day 3 following colorectal ESD to optimize patient safety.
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Participation and Yield in Multiple Rounds of Colorectal Cancer Screening Based on Fecal Immunochemical Test: A Systematic Review and Meta-Analysis

The American Journal of Gastroenterology |

Author: Yueyang Zhou

This systematic review evaluates participation rates and diagnostic outcomes across multiple rounds of colorectal cancer screening using fecal immunochemical testing (FIT).
Understanding participation and yield trends can help improve CRC screening program design and effectiveness.
A meta-analysis of longitudinal studies examining participation rates and detection of advanced neoplasia in multiple rounds of FIT-based CRC screening.
Participation tends to decline in subsequent rounds, but detection rates for advanced neoplasia remain consistent.
Efforts should focus on increasing adherence to repeated screening rounds to maximize the benefits of FIT-based CRC screening.
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Glucagon-Like Peptide Receptor Agonists Use Before Endoscopy Is Associated With Low Retained Gastric Contents: A Multicenter Cross-Sectional Analysis

The American Journal of Gastroenterology |

Author: Jennifer Phan

This study explores whether pre-endoscopy use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) leads to delayed gastric emptying and retained stomach contents.
The findings clarify the safety of performing endoscopy in patients on GLP-1 RAs, addressing concerns about increased aspiration risk.
A multicenter cross-sectional analysis of patients undergoing upper endoscopy, comparing retained gastric content volumes between GLP-1 RA users and non-users.
Contrary to prior concerns, GLP-1 RA use was associated with lower retained gastric contents.
Routine withholding of GLP-1 RAs before upper endoscopy may not be necessary, though clinical judgment should guide decision-making.
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The Liver Cirrhosis Network Cohort Study: Cirrhosis Definition, Study Population, and Endpoints

The American Journal of Gastroenterology |

Author: Elliot B. Tapper

The Liver Cirrhosis Network Cohort Study establishes standardized definitions, population criteria, and study endpoints for cirrhosis research.
Standardization facilitates reproducible and comparable cirrhosis studies, addressing prior inconsistencies in research.
The study provides a framework for future cirrhosis research that is rigorous, transparent, and comparable across studies.
Clinicians and researchers should use standardized definitions and endpoints when designing or interpreting cirrhosis studies.
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Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies

The American Journal of Gastroenterology |

Author: Morten Daniel Jensen

This study evaluates the risk of hepatocellular carcinoma (HCC) and mortality among patients with alcohol-related cirrhosis in two European countries.
Better understanding HCC risk can inform targeted screening and prevention strategies in patients with alcohol-related cirrhosis.
Observational cohort studies from England and Denmark analyzing population-level data on alcohol-related cirrhosis outcomes.
Patients with alcohol-related cirrhosis have high risks of primary liver cancer and mortality, emphasizing the need for surveillance.
Implement liver cancer surveillance programs for patients with alcohol-related cirrhosis to detect HCC early and improve survival.
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