Gastroenterology

- Marianna Parlato, Fabienne Charbit-Henrion, Elie Abi Nader, Bernadette Begue, Nicolas Guegan, Julie Bruneau, Shérine Khater, Elizabeth Macintyre, Capucine Picard, F. Rieux-Laucat, Lionel Le Bourhis, Matthieu Allez, Olivier Goulet, Christophe Cellier, Olivier Hermine, Nadine Cerf-Bensussan, Georgia Malamut

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- Lorenzo Fuccio, Douglas Rex, Thierry Ponchon, Leonardo Frazzoni, Mário Dinis-Ribeiro, Pradeep Bhandari, Evelien Dekker, Maria Pellisè, Loredana Correale, Jeanin van Hooft, Rodrigo Jover, Diogo Libanio, Franco Radaelli, Sergio Alfieri, Franco Bazzoli, Carlo Senore, Jaroslaw Regula, Thomas Seufferlein, Thomas Rösch, Prateek Sharma, Alessandro Repici, Cesare Hassan

Outcomes of endoscopic surveillance following surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection, at anastomoses or non- anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. [...]

- Aadra P. Bhatt, Luca Grillo, Matthew R. Redinbo

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- Daniel Triner, Samantha N. Devenport, Sadeesh K. Ramakrishnan, Xiaoya Ma, Ryan A. Frieler, Joel K. Greenson, Naohiro Inohara, Gabriel Nunez, Justin A. Colacino, Richard M. Mortensen, Yatrik M. Shah

Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis. [...]

- V. Svolos, R. Hansen, B. Nichols, C. Quince, U.Z. Ijaz, R.T. Papadopoulou, C.A. Edwards, D. Watson, A. Alghamdi, A. Brejnrod, C. Ansalone, H. Duncan, L. Gervais, R. Tayler, J. Salmond, D. Bolognini, R. Klopfleisch, D.R. Gaya, S. Milling, R.K. Russell, K. Gerasimidis

Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn’s disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD. [...]

- Jane Varney, Jane G. Muir, Peter R. Gibson

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- Sudarshan Paramsothy, Shaun Nielsen, Michael A. Kamm, Nandan P. Deshpande, Jeremiah J. Faith, Jose C. Clemente, Ramesh Paramsothy, Alissa J. Walsh, Johan van den Bogaerde, Douglas Samuel, Rupert W.L. Leong, Susan Connor, Watson Ng, Enmoore Lin, Thomas J. Borody, Marc R. Wilkins, Jean-Frederic Colombel, Hazel M. Mitchell, Nadeem O. Kaakoush

Fecal microbiota transplantation (FMT) can induce remission in patients with ulcerative colitis (UC). In a randomized, controlled trial of FMT in patients with active UC, we aimed to identify bacterial taxonomic and functional factors associated with response to therapy. [...]

- Remi Mahmoud, Shailja C. Shah, Joren R. ten Hove, Joana Torres, Erik Mooiweer, Daniel Castaneda, Jason Glass, Jordan Elman, Akash Kumar, Jordan Axelrad, Thomas Ullman, Jean-Frederic Colombel, Bas Oldenburg, Steven H. Itzkowitz, Dutch initiative on Crohn and Colitis (ICC)

Patients with inflammatory bowel diseases (IBD) who have post-inflammatory polyps (PIPs) have an increased risk of colorectal neoplasia (CRN). European guidelines propose that patients with PIPs receive more frequent surveillance colonoscopies, despite limited evidence of this increased risk. We aimed to define the risk of CRN and colectomy in patients with IBD and PIPs. [...]

- Yingchang Lu, Sun-Seog Kweon, Chizu Tanikawa, Wei-Hua Jia, Yong-Bing Xiang, Qiuyin Cai, Chenjie Zeng, Stephanie L. Schmit, Aesun Shin, Keitaro Matsuo, Sun Ha Jee, Dong-Hyun Kim, Jeongseon Kim, Wanqing Wen, Jiajun Shi, Xingyi Guo, Bingshan Li, Nan Wang, Ben Zhang, Xinxiang Li, Min-Ho Shin, Hong-Lan Li, Zefang Ren, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, David V. Conti, Fredrick R. Schumacher, Gad Rennert, Mark A. Jenkins, Peter T. Campbell, Michael Hoffmeister, Graham Casey, Stephen B. Gruber, Jing Gao, Yu-Tang Gao, Zhi-Zhong Pan, Yoichiro Kamatani, Yi-Xin Zeng, Xiao-Ou Shu, Jirong Long, Koichi Matsuda, Wei Zheng

In a study of more than 60,000 East Asian descendants, 13 new genetic loci were discovered that are associated with an increased risk of colorectal cancer. [...]