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- Elize M. da Fonseca

New England Journal of Medicine, Volume 380, Issue 7, Page 605-607, February 2019. [...]

- Suerie Moon

New England Journal of Medicine, Volume 380, Issue 7, Page 607-610, February 2019. [...]

- Mark A. Hall

New England Journal of Medicine, Volume 380, Issue 7, Page 610-612, February 2019. [...]

- Tatiana M. Prowell

New England Journal of Medicine, Volume 380, Issue 7, Page 612-615, February 2019. [...]

- Gunter von Minckwitz

New England Journal of Medicine, Volume 380, Issue 7, Page 617-628, February 2019. [...]

- Peter Hajek

New England Journal of Medicine, Volume 380, Issue 7, Page 629-637, February 2019. [...]

- Susan S. Huang

New England Journal of Medicine, Volume 380, Issue 7, Page 638-650, February 2019. [...]

- Lionel A. Mandell

New England Journal of Medicine, Volume 380, Issue 7, Page 651-663, February 2019. [...]

- Shelby Leuin

New England Journal of Medicine, Volume 380, Issue 7, Page 664-664, February 2019. [...]

- Julie Ng

New England Journal of Medicine, Volume 380, Issue 7, February 2019. [...]

- Charlotte Hogan

New England Journal of Medicine, Volume 380, Issue 7, Page 665-674, February 2019. [...]

- Daniel F. Hayes

New England Journal of Medicine, Volume 380, Issue 7, Page 676-677, February 2019. [...]

- Belinda Borrelli

New England Journal of Medicine, Volume 380, Issue 7, Page 678-679, February 2019. [...]

- Jeffrey M. Drazen

New England Journal of Medicine, Volume 380, Issue 7, Page 679-680, February 2019. [...]

- Stefano Romeo

New England Journal of Medicine, Volume 380, Issue 7, Page 681-683, February 2019. [...]

Blood heating and cooling machines used during heart bypass were linked to 20 cases of Mycobacterium chimaera in California patients in 2016, according to a CDC report. [...]

A rare 9-person outbreak of wound botulism in California was traced to use of black tar heroin, according to a CDC report. [...]

This 2019 Recommendation Statement from the US Preventive Services Task Force recommends that clinicians provide or refer pregnant and postpartum persons at increased risk of perinatal depression to counseling interventions, such as cognitive behavioral or interpersonal therapy (B recommendation). [...]

This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on interventions to prevent perinatal depression summarizes published evidence on the benefits and harms of primary care–relevant interventions to prevent depression during pregnancy or up to 1 year after childbirth. [...]


In this narrative medicine essay a physician recalls the connections she has forged with patients through conversations about their tattoos and reveals how she considers herself tattooed with the narratives and experiences they’ve shared. [...]

So blank, so lulled,I lived the seasons like a forest;so lank, so mild,the days disguised a warfare harvest. [...]

This JAMA Patient Page explains the US Preventive Services Task Force’s 2019 recommendations to provide or refer pregnant and postpartum women at risk of perinatal depression to counseling interventions such as cognitive behavioral therapy and interpersonal therapy. [...]

This cohort study found that 90-day mortality following elective noncardiac surgery was higher among Veterans Affairs patients with symptomatic or asymptomatic heart failure and reduced left ventricular ejection fraction (LVEF) compared with patients without heart failure. [...]

This randomized clinical trial compares the effects of combination paracetamol (acetaminophen) and ibuprofen at full vs half strength vs either drug alone on 24-hour patient-controlled morphine consumption and 90-day serious adverse events after total hip arthroplasty (THA). [...]

In Reply Dr Rodríguez-Baño and colleagues comment that our findings, in which 30-day all-cause mortality was 12.3% (23/187) of patients randomized to piperacillin-tazobactam compared with 3.7% (7/191) randomized to meropenem, stand in contrast to retrospective observational studies in which outcomes were similar between the 2 groups. In any observational study, the choice of antimicrobial is made by the clinician and is affected by clinical impression of how sick the patient is. Not surprisingly [...]

In Reply Dr Dickinson raises the question as to why the USPSTF recommended screening for cervical cancer with cervical cytology every 3 years in women aged 21 to 29 years (A recommendation) rather than starting at age 25 years. In support of starting screening at a later age, he cites the low incidence of cervical cancer in younger women, a case-control study showing no benefit in screening women aged 22 to 24 years vs 25 to 29 years, and clinical data from Wales reporting follow-up testing rate [...]

To the Editor Dr Harris and colleagues conducted a well-designed study investigating whether carbapenems for extended-spectrum β-lactamase–producing enterobacteria could be spared. The results should be interpreted with caution. [...]

To the Editor The MERINO trial found that piperacillin-tazobactam did not result in noninferior 30-day mortality in patients with Escherichia coli or Klebsiella pneumoniae bloodstream infections and ceftriaxone resistance, compared with meropenem. We think there might be reasons to explain the results other than differences in effectiveness of the antibiotic regimens. [...]

To the Editor The US Preventive Services Task Force (USPSTF) recently recommended screening for cervical cancer every 3 years with cervical cytology in women aged 21 to 29 years (A recommendation). I question why cervical screening is recommended starting at age 21 years rather than 25 years. For unscreened women younger than 25 years, the incidence of invasive cervical cancer is extremely low. Many other countries with evidence-based national policies start screening at age 25 years or even 30 [...]

- Takeshi Tomoda, Hironari Kato, Toru Ueki, Yutaka Akimoto, Hidenori Hata, Masakuni Fujii, Ryo Harada, Tsuneyoshi Ogawa, Masaki Wato, Masahiro Takatani, Minoru Matsubara, Yoshinari Kawai, Hiroyuki Okada

Acute pancreatitis is a major adverse event of endoscopic retrograde cholangiopancreatography (ERCP). Rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the incidence of post-ERCP pancreatitis (PEP). Little is known about the combined effects of sublingual nitrate and NSAIDs. We performed a randomized trial to assess whether the combination of NSAIDs and sublingual nitrate is more effective than NSAIDs alone in preventing PEP. [...]

- Anders Dige, Helene Tarri Hougaard, Jørgen Agnholt, Bodil Ginnerup Pedersen, Michaela Tencerova, Moustapha Kassem, Klaus Krogh, Lilli Lundby

Perianal fistulas are common in patients with Crohn´s disease (CD). Injections of cultured autologous and allogeneic adipose tissue-derived stem cells have been shown to heal CD-associated fistulas. Unfortunately, this treatment is time-consuming and expensive. We investigated the effects of injecting freshly collected autologous adipose tissue into perianal fistulas in patients with CD. [...]

- Charles N. Bernstein, Charles Burchill, Laura E. Targownik, Harminder Singh, Leslie L. Roos

We performed a population-based study to determine whether there was an increased risk of inflammatory bowel diseases (IBD) in persons with critical events at birth and within 1 year of age. [...]

- Sonia S. Kupfer, Shazia Mehmood Siddique, Deborah D. Proctor


- Meritxell Canals, Daniel P. Poole, Nicholas A. Veldhuis, Brian L. Schmidt, Nigel W. Bunnett

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. GPCRs are the target of over one third of therapeutic drugs, including many drugs used to treat [...]

- Nicolas M. Intagliata, Stephen H. Caldwell, Armando Tripodi

Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis but less frequently observed in patients without cirrhosis. Prompt diagnosis and management of acute symptomatic portal vein thrombosis are essential. Failure to detect and treat thromboses can result in mesenteric ischemia, chronic cavernous transformation, and complications of portal hypertension. In patients with cirrhosis, development of portal vein thrombosis is often insidious and remains undetected u [...]

- Junfeng Wang, Rui Dong, Shan Zheng


- Andrew E. Blum, Srividya Venkitachalam, Durgadevi Ravillah, Aruna K. Chelluboyina, Ann Marie Kieber-Emmons, Lakshmeswari Ravi, Adam Kresak, Apoorva K. Chandar, Sanford D. Markowitz, Marcia I. Canto, Jean S. Wang, Nicholas J. Shaheen, Yan Guo, Yu Shyr, Joseph E. Willis, Amitabh Chak, Vinay Varadan, Kishore Guda

Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to slow tumor growth or progression. [...]

- Pietro Mascagni, Sun Gyo Lim, Claudio Fiorillo, Philippe Zanne, Florent Nageotte, Lucile Zorn, Silvana Perretta, Michel de Mathelin, Jacques Marescaux, Bernard Dallemagne


- Hadi Karimzadeh, Muthamia M. Kiraithe, Valerie Oberhardt, Elahe Salimi Alizei, Jan Bockmann, Julian Schulze zur Wiesch, Bettina Budeus, Daniel Hoffmann, Heiner Wedemeyer, Markus Cornberg, Adalbert Krawczyk, Jassin Rashidi-Alavijeh, Francisco Rodríguez-Frías, Rosario Casillas, Maria Buti, Antonina Smedile, Seyed Moayed Alavian, Andreas Heinold, Florian Emmerich, Marcus Panning, Emma Gostick, David A. Price, Jörg Timm, Maike Hofmann, Bijan Raziorrouh, Robert Thimme, Ulrike Protzer, Michael Roggendorf, Christoph Neumann-Haefelin

Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8+ T cells are thought to control the virus, little is known about which HDV epitopes are targeted by virus-specific CD8+ T cells or why these cells ultimately fail to control the infection. We aimed to define how HDV escapes the CD8+ T cell-mediate [...]

- Vrishketan Sethi, Gerardo A. Vitiello, Deepak Saxena, George Miller, Vikas Dudeja

Our understanding of the microbiome and its role in immunity, cancer initiation, and cancer progression has evolved significantly over the past century. The “germ theory of cancer” was first proposed in the early 20th century, and shortly thereafter the bacterium Helicobacter pylori and later, Fusobacterium nucleatum were implicated in the development of gastric and colorectal cancers respectively. However, with the development of reliable mouse models and affordable sequencing technologies, the [...]

- Pramod K. Garg, Vijay P. Singh

Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines ‘severe acute pancreatitis’. Organ failure typically develops early in the course of acute pancreatitis, but may also develop later due to infected pancreatic necrosis induced sepsis. Organ failure is the most important determinant of outcome in acute pancreatitis. We review here t [...]

- Dominique Thabut, Christophe Bureau, Richard Layese, Valérie Bourcier, Maryam Hammouche, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Odile Goria, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle-Bladou, Thông Dao, Christophe Pilette, Christine Silvain, Christos Christidis, Dominique Capron, Brigitte Bernard-Chabert, Sophie Hillaire, Vincent Di Martino, Angela Sutton, Etienne Audureau, Françoise Roudot-Thoraval, Pierre Nahon, ANRS CO12 CirVir group

Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelin [...]

- Chetan Mittal

Technical Advances in Per-Oral Endoscopic Myotomy (POEM) American Journal of Gastroenterology 112, 1627 (November 2017). doi:10.1038/ajg.2017.369 Authors: Chetan Mittal & Mihir S Wagh [...]

- Neehar D Parikh

PRO: Hepatocellular Carcinoma Surveillance: A Useful Tool Against the Rising Tide of HCC American Journal of Gastroenterology 112, 1632 (November 2017). doi:10.1038/ajg.2017.366 Author: Neehar D Parikh [...]

- Amit G Singal

CON: Hepatocellular Carcinoma Surveillance: In Need of Higher-Quality Data American Journal of Gastroenterology 112, 1634 (November 2017). doi:10.1038/ajg.2017.374 Author: Amit G Singal [...]

- Koichiro Abe

Inflammatory Bowel Disease in an Elderly Woman After Nivolumab Administration American Journal of Gastroenterology 112, 1636 (November 2017). doi:10.1038/ajg.2017.372 Authors: Koichiro Abe, Naohiro Nakamura, Akari Isono, Hikaru Toyota, Hidenori Arai & Koji Saito [...]

- Wala Ben Kridis

Lower-Extremity Vasospasm Caused by Carcinoid Syndrome American Journal of Gastroenterology 112, 1636 (November 2017). doi:10.1038/ajg.2017.289 Authors: Wala Ben Kridis, Zeinab Guermazi, Héla Mnif, Nabil Toumi, Afef Khanfir, Tahia Boudawara & Mounir Frikha [...]

- Min Kyung Jeon

Fluoroscopic-Assisted, EUS-Guided Trans-Sigmoidal Pancreas Biopsy in a Patient with Surgically Altered Anatomy American Journal of Gastroenterology 112, 1637 (November 2017). doi:10.1038/ajg.2017.209 Authors: Min Kyung Jeon, Hoonsub So & Do Hyun Park [...]

- Shuichi Miyamoto

Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma American Journal of Gastroenterology 112, 1638 (November 2017). doi:10.1038/ajg.2017.276 Authors: Shuichi Miyamoto, Takahiko Kudo, Satoshi Abiko, Shouko Ono, Yuichi Shimizu, Yoshihiro Matsuno & Naoya Sakamoto [...]

Continuing Medical Education: November 2017: Complications of Bariatric Surgery: What You Can Expect to See in Your GI Practice American Journal of Gastroenterology 112, 1639 (November 2017). doi:10.1038/ajg.2017.406 [...]

- Allison R Schulman

Complications of Bariatric Surgery: What You Can Expect to See in Your GI Practice American Journal of Gastroenterology 112, 1640 (November 2017). doi:10.1038/ajg.2017.241 Authors: Allison R Schulman & Christopher C Thompson [...]

- Christine Hachem

Continuing Medical Education Questions: November 2017: Complications of Bariatric Surgery: What You Can Expect to See in Your GI Practice American Journal of Gastroenterology 112, 1656 (November 2017). doi:10.1038/ajg.2017.412 Author: Christine Hachem [...]

Continuing Medical Education: November 2017: Systematic Review: Disease Activity Indices in Eosinophilic Esophagitis American Journal of Gastroenterology 112, 1657 (November 2017). doi:10.1038/ajg.2017.413 [...]

- Marijn J Warners

Systematic Review: Disease Activity Indices in Eosinophilic Esophagitis American Journal of Gastroenterology 112, 1658 (November 2017). doi:10.1038/ajg.2017.363 Authors: Marijn J Warners, Pieter Hindryckx, Barrett G Levesque, Claire E Parker, Lisa M Shackelton, Reena Khanna, William J Sandborn, Geert R D'Haens, Brian G Feagan, Albert J Bredenoord & Vipul Jairath [...]

- Fouad J Moawad

Continuing Medical Education Questions: November 2017: Systematic Review: Disease Activity Indices in Eosinophilic Esophagitis American Journal of Gastroenterology 112, 1670 (November 2017). doi:10.1038/ajg.2017.414 Authors: Fouad J Moawad & Scripps Health La Jolla [...]

- Thomas V K Herregods

Determinants of the Association between Non-Cardiac Chest Pain and Reflux American Journal of Gastroenterology 112, 1671 (November 2017). doi:10.1038/ajg.2017.288 Authors: Thomas V K Herregods, Albert J Bredenoord, Jacobus M Oors, Auke Bogte & André J P M Smout [...]

- Joel H Rubenstein

Overuse of Repeat Upper Endoscopy in the Veterans Health Administration: A Retrospective Analysis American Journal of Gastroenterology 112, 1678 (November 2017). doi:10.1038/ajg.2017.192 Authors: Joel H Rubenstein, Heiko Pohl, Megan A Adams, Eve Kerr, Robert Holleman, Sandeep Vijan, Jason A Dominitz, John M Inadomi, Dawn Provenzale, Joseph Francis & Sameer D Saini [...]

- Masaya Iwamuro, Hiroyuki Sakae, Takehiro Tanaka, Hiroyuki Okada


- Cheng-Lu Lin, Kuan-Chih Chen, Cheng-Kuan Lin, Chien-Chen Tsai, Tzong-Hsi Lee, Chen-Shuan Chung


- Sachin Wani, Samuel Han, Violette Simon, Matthew Hall, Dayna Early, Eva Aagaard, Wasif M. Abidi, Subhas Banerjee, Todd H. Baron, Michael Bartel, Erik Bowman, Brian C. Brauer, Jonathan M. Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A. Coté, Koushik K. Das, Christopher J. DiMaio, Andrew M. Dries, Steven A. Edmundowicz, Abdul Hamid El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S. Gan, Lisa Gangarosa, Bhargava Gannavarapu, Stuart R. Gordon, Nalini M. Guda, Hazem T. Hammad, Cynthia Harris, Sujai Jalaj, Paul Jowell, Sana Kenshil, Jason Klapman, Michael L. Kochman, Sri Komanduri, Gabriel Lang, Linda S. Lee, David E. Loren, Frank Lukens, Daniel Mullady, Raman V. Muthusamy, Andrew S. Nett, Mojtaba S. Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M. Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M. Scheiman, Isaiah Schuster, Raj J. Shah, Rishi Sharma, Joshua P. Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H. Tabibian, Demetrios Tzimas, Dushant S. Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y. Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Rajesh N. Keswani

Minimum EUS and ERCP volumes that should be offered per trainee in “high quality” advanced endoscopy training programs (AETPs) are not established. We aimed to define the number of procedures required by an “average” advanced endoscopy trainee (AET) to achieve competence in technical and cognitive EUS and ERCP tasks to help structure AETPs. [...]

- Jacob E. Ollech, Maya Aharoni-Golan, Roni Weisshof, Inessa Normatov, Abby R. Sapp, Aditya Kalakonda, Amanda Israel, Laura Glick, Theodore Karrison, Sushila R. Dalal, Atsushi Sakuraba, Russell D. Cohen, David T. Rubin, Joel Pekow

It is standard of care to perform ileocolonoscopy within a year of ileocolonic resection for Crohn’s disease (CD) and to guide management decisions based on the Rutgeert score (RS). The modified RS subdivides i2 into lesions confined to the anastomosis (i2a) or >5 aphthous lesions in the neoterminal ileum (i2b). There is uncertainty, however, if i2a lesions incur an increased risk of disease recurrence. The primary aim of this study was to compare the rates of endoscopic progression between i [...]

- Ali Alshati, Toufic Kachaamy


- Takahito Takezawa, Yoshikazu Hayashi, Satoshi Shinozaki, Yuichi Sagara, Masahiro Okada, Yasutoshi Kobayashi, Hirotsugu Sakamoto, Yoshimasa Miura, Keijiro Sunada, Alan Kawarai Lefor, Hironori Yamamoto

Colonic endoscopic submucosal dissection (ESD) is more difficult than rectal ESD because of poor maneuverability of the endoscope due to physiological flexion, peristalsis and respiratory movements. The aim of this study is to assess the usefulness of the pocket-creation method (PCM) for colonic ESD compared with the conventional method (CM) regardless of lesion shape or location. [...]

- Nan Lan, Luca Stocchi, Conor P. Delaney, Tracy L. Hull, Bo Shen

Endoscopic stricturotomy is a novel technique in the treatment of anastomotic strictures in Crohn’s disease (CD). The aim of this study was to compare the outcome of patients with ileocolonic anastomotic stricture treated with endoscopic stricturotomy (ESt) versus ileocolonic resection (ICR). [...]

- Mónica Garrido, Fernando Castro-Poças


- Cheal Wung Huh, Joon Sung Kim, Hyun Ho Choi, I So Maeng, Sun-Young Jun, Byung-Wook Kim

Cold snare polypectomy (CSP) and jumbo forceps polypectomy (JFP) have been shown to be effective for removing diminutive colorectal polyps (DCPs) (≤5 mm). However, no study has compared complete resection rates between CSP and JFP for DCPs. The aim of this study was to compare the efficacy and safety of JFP to CSP for the removal of DCPs. [...]

- Kulwinder S. Dua, John M. DeWitt, William R. Kessler, David L. Diehl, Peter V. Draganov, Mihir S. Wagh, Michel Kahaleh, Louis M. Wong Kee Song, Harshit S. Khara, Abdul H. Khan, Murad M. Aburajab, Darren Ballard, Chris E. Forsmark, Steven A. Edmundowicz, Brian C. Brauer, Amy Tyberg, Najtej S. Buttar, Douglas G. Adler

Self-expanding metal stents (SEMSs) when deployed across the gastroesophageal junction (GEJ) can lead to reflux with risks of aspiration. A SEMS with a tricuspid anti-reflux valve (SEMS-V) was designed to address this issue. The aim of this study was to evaluate the efficacy and safety of this stent. [...]

- Nam Hee Kim, Yoon Suk Jung, Jae Wan Lim, Jung Ho Park, Dong Il Park, Chong Il Sohn

A fecal immunochemical test (FIT) is often repeated annually, even after a recent colonoscopy. However, there are no published data on the proper approach to FIT-positive patients after a recent colonoscopy. We compared colorectal cancer (CRC) and advanced colorectal neoplasia (ACRN) prevalence based on the interval since the last colonoscopy. [...]

- Shengbing Zhao, Xia Yang, Qianqian Meng, Shuling Wang, Jun Fang, Wei Qian, Tian Xia, Peng Pan, Zhijie Wang, Lun Gu, Xin Chang, Duowu Zou, Zhaoshen Li, Yu Bai

Colonoscopy insertion is painful for some patients, constituting one of the main barriers to screening colonoscopy. Few studies have assessed the impact of the supine position (SP) on colonoscopy insertion, especially for unsedated patients. The aim of this randomized controlled trial (RCT) is to clarify this issue. [...]