Wilson’s Disease Scoring System

Kayser-Fleischer Rings :
Neurologic Symptoms :
Serum Ceruloplasmin :
Coombs-negative Hemolytic Anemia :
Liver Copper (in the absence of cholestasis) :
Urinary Copper (in the absence of cholestasis) :
Mutation Analysis :

The Wilson’s Disease Scoring System predicts the likelihood of having Wilson’s disease based on clinical and chemical analysis.

Formula :

Points are given for each variable.

Explanation of Result :

4 or more: Diagnosis established
3: Diagnosis possible, more tests needed
2 or less: Diagnosis very unlikely

* Please verify all calculations prior to clinical use.

References

  • European Association for Study of Liver. EASL Clinical Practice Guidelines: Wilson’s disease. J Hepatol. 2012 Mar;56(3):671-85. PMID: 22340672.