The R factor is used to assess the laboratories to assess if the liver injury seen is due to cholestatic or hepatocellular process.
( ALT * Upper Limit of Normal Alk Phos ) / ( Alk Phos x Upper Limit of Normal ALT )
Explanation of Result :
More information on DILI (Drug Induced Liver Injury) can be found at livertox.nih.gov.
>=5 is consistent with hepatocellular damage.
* Please verify all calculations prior to clinical use.
- DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec;24(4):787-810. PMID: 8749899.