R Factor
ALT :
Upper Limit of Normal ALT :
Alkaline Phosphatase :
Upper Limit of Normal Alk Phos :

The R factor is used to assess the laboratories to assess if the liver injury seen is due to cholestatic or hepatocellular process.


Formula :

( ALT * Upper Limit of Normal Alk Phos ) / ( Alk Phos x Upper Limit of Normal ALT )

Explanation of Result :

>=5 is consistent with hepatocellular damage.

* Please verify all calculations prior to clinical use.

Reference(s) :

  • DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec;24(4):787-810. PMID: 8749899.
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