R Factor

R Factor

ALT :
Upper Limit of Normal ALT :
Alkaline Phosphatase :
Upper Limit of Normal Alk Phos :

The R factor is used to assess the laboratories to assess if the liver injury seen is due to cholestatic or hepatocellular process.

Formula :

( ALT * Upper Limit of Normal Alk Phos ) / ( Alk Phos x Upper Limit of Normal ALT )

Explanation of Result :

More information on DILI (Drug Induced Liver Injury) can be found at livertox.nih.gov.

>=5 is consistent with hepatocellular damage.

* Please verify all calculations prior to clinical use.

References

  • DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec;24(4):787-810. PMID: 8749899.