Pohl Score

Pohl Score

[php]
if ($_POST) {
$a = $_POST[‘ast’];
$b = $_POST[‘alt’];
$c = $_POST[‘plt’];

if ((empty($a)) || (empty($b)) || (empty($c))) {
$result = “Fill in all variables”;
}if (empty($result)) {
$var1 = $a / $b;
if ($c >= 150) {
$var2 = “1”;
}
if ($c < 150) { $var2 = "0"; } if ($var2 == 1) { $result = "Excludes advanced fibrosis (Metavir F3/4)"; } if (($var1 < 1) AND ($var2 == 0)) { $result = "Excludes advanced fibrosis (Metavir F3/4)"; } if (($var1 > 0.99) AND ($var2 == 0)) {
$result = “Advanced fibrosis (Metavir F3/4)”;
}

}

echo $result;
echo “*”;
}
[/php]
AST :
ALT :
Platelet Count (10^9/L) :

[pullquote]In patients with Hepatitis C with AST/ALT less than 1 and platelets less than 150,000 are excluded from marked fibrosis.[/pullquote]

Formula :

If AST/ALT less than 1 and platelets > 150,000 than excludes marked fibrosis

Explanation of Result :

For patients without history of alcohol abuse, the correlation between disease stage, AST/ALT ratio, and platelet counts was r = 0.297, p < 0.00, and r = 0.560, p < 0.00, respectively. In these patients, AST/ALT ratio > or =1 in combination with a platelet count of <150,000/mm3 can identify patients with severe fibrosis or cirrhosis (stages 3 and 4) with a positive predictive value of 93.1%. Sensitivity, specificity, and negative predictive value were 41.2%, 99.1%, and 85.0%, respectively. In patients with ALT/AST ratio of <1 or platelet counts of >150,000/mm3, these laboratory parameters cannot predict liver fibrosis stage.

* Please verify all calculations prior to clinical use.