Maddrey Discriminant Score

Prothrombin Time (PT) :
Control PT :
Total Bilirubin :

The Maddrey Discriminant Function is a calculation for patients with alcoholic hepatitis and stratifies them for risk of mortality and the use of steroids.

Formula : 4.6 * ( PT – Control PT ) + Tbili )

Explanation of Result : If > 32 indicates a poor prognosis and potential for steroid use. * Please verify all calculations prior to clinical use.


  • Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978 Aug;75(2):193-9. PMID: 352788.