GIHep

Gastroenterology & Hepatology Resources

Lille Model

Age :
Albumin on day 0:
Total Bilirubin at day 0 :
Total Bilirubin at day 7 :
Creatinine at day 0 :
PT at day 0 :

The Lille model is based on a composite score looking at survival in patients with ETOH hepatitis.

Formula :

3.19 – 0.101 * (age in
years) + 0.147 * (albumin day 0 in g/L) + 0.0165 *
(evolution in bilirubin level in M) - (0.206 * renal
insufficiency) - 0.0065 * (bilirubin day 0 in M) -
0.0096 * (PT). Note made that original publication failed to add in exp (-R) / 1 + exp(-R) where R is the above formula.

Explanation of Result :

A score of >0.45 identifies 75% of deaths. A score of >0.45 predicts a 6-month survival of 25%, versus 85% survival when the score is <0.45.

* Please verify all calculations prior to clinical use.

References

  • Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, Dharancy S, Texier F, Hollebecque A, Serfaty L, Boleslawski E, Deltenre P, Canva V, Pruvot FR, Mathurin P. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007 Jun;45(6):1348-54. PMID: 17518367.