Fibrosis 4 Score

Age :
Platelet Count :
Using ukat/L for ALT/AST? :

The Fibrosis 4 score is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver. This score has been studied in liver disease due to Hepatitis C and NASH.

Formula :

( Age x AST ) / ( Platelts x ( sqr ( ALT ) )

Explanation of Result :

For NASH : Fib4 score < 1.30 = F0-F1Fib4 score > 2.67 = F3-F4

For HCV with or without HIV : Fib4 score < 1.45 = F0-F1Fib4 score > 3.25 = F3-F4


  • Kim BK1, Kim DY, Park JY, Ahn SH, Chon CY, Kim JK, Paik YH, Lee KS, Park YN, Han KH. Validation of FIB-4 and comparison with other simple noninvasive indices for predicting liver fibrosis and cirrhosis in hepatitis B virus-infected patients. Liver Int. 2010 Apr;30(4):546-53. PMID: 20074094.
  • Shah AG1, Lydecker A, Murray K, Tetri BN, Contos MJ, Sanyal AJ; Nash Clinical Research Network. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009 Oct;7(10):1104-12. PMID: 19523535.