CLIP Scoring System for HCC

Child-Pugh Stage :
Tumor Morphology :
AFP (ng/dL) :
Portal Vein Thrombosis :

The CLIP score for a patient with hepatocellular carcinoma is calculated by assigning a score.

Formula :

Points are given for each variable.

Explanation of Result :

The CLIP score for a patient with hepatocellular carcinoma is calculated by assigning a score (0, 1 or 2) to each of four clinical factors: a) Child-Pugh stage; b) number of tumor nodules and whether the tumor extends through <=50% or >50% of the liver; c) AFP; and d) portal vein thrombosis.

Median Survival :
0 = 42.5 months
1 = 32.0 months
2 = 16.5 months
3 = 4.5 months
4 = 2.5 months
5-6 = 1 month

* Please verify all calculations prior to clinical use.

References

  • Kudo M, Chung H, Osaki Y. Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score). J Gastroenterol. 2003;38(3):207-15. PMID: 12673442.