AST to ALT Ratio


A crude measure of fibrosis in patients with Hepatitis C.

Formula :

( AST / ALT )

Explanation of Result :

Highly predictive of cirrhosis if ratio > 1
100% specificity and positive predictive value in distinguishing cirrhotic from noncirrhotic patients, with a 53.2% sensitivity and 80.7% negative predictive value.

* Please verify all calculations prior to clinical use.


  • Sheth SG1, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 1998 Jan;93(1):44-8. PMID: 9448172.