In patients with NAFLD and Hepatitis C, APRI values tend to increase with the degree of fibrosis.
Formula
[( AST / ULN AST ) x 100] / Platelets (109/L)
Explanation
For NAFLD APRI values of < or = 0.3 and < or = 0.5 rule out significant fibrosis and cirrhosis, and a value of ≥ 1.5 rules in significant fibrosis. For Hepatitis C the ROC curves showed a concordance of 92% and 88.5% when 1.05 was the cut off (F3 and F4), and 87% and 83%, on 0.75 cut offs (F2-F4).